Subject: Basic medicine
Subject: Chemical engineering
Subject: Chemical sciences
Year: 2024
Type: Conference or Workshop Item
Type: PeerReviewed
Title: Quantum Chemical calculations of lattice energy for Clopidogrel picrate pseudopolymorphs
Author: Cvetkovski, Aleksandar
Abstract: The purpose of engineering multicomponent crystals of drug model Clopidogrel, potent antiplatelet drug, marketed as hydrogen sulfate salt (ClopH+•HSO4 −) in Plavix® (BMS-Sanofi), encompassed cocrystallization screening of clopidogrel deprotonated (free) base with coformers from the range of organic acids. The reported crystal structures relate to obtained two pseudopolymorphic forms of S(+)clopidogrel–picrate. Form 1 crystallizes in the monoclinic space group P21 with an ionic couple S(+)ClopH+•Pic− and a molecule of solvent ethanol in the asymmetric unit, while Form 2 crystallizes in the monoclinic space group C2 with two ionic couples in the asymmetric unit. The configurations and conformations of the ionic couples, held together by ionized +N-H···O hydrogen bonds, are nearly identical in the structures. [1]
Publisher:
Relation: https://eprints.ugd.edu.mk/36272/
Identifier: oai:eprints.ugd.edu.mk:36272
Identifier: https://eprints.ugd.edu.mk/36272/1/Poster_CA22107_Zagreb_AC.pdfIdentifier: Cvetkovski, Aleksandar (2024) Quantum Chemical calculations of lattice energy for Clopidogrel picrate pseudopolymorphs. In: COST CA 22107 BEST-CST Project Meeting, 25-26 May 2024, Zagreb, Croatia.
