Subject: Basic medicine
Subject: Chemical engineering
Subject: Chemical sciences
Subject: Materials engineering
Subject: Nano-technology
Year: 2023
Type: Article
Type: PeerReviewed
Title: Influence of beta-cyclodextrin on the phase transition in carbamazepine polymorphs
Author: Cvetkovski, Aleksandar
Author: Drakalska, Elena
Abstract: Results confirm that phase transition of CBZ polymorphs, anhydrous form III and I leading to less water soluble CBZ pseudopolymoprph, dihydrate form during the kneading and formation of IC with BCD occur simultaneously. Less water soluble and stable at ambient temperature CBZ III, thus less favorable for transition in CBZ dihydrate, in grinded binary sample with BCD exerts higher water solubility due to formation of IC. BCD in high extent retains inhibition of phase transition of CBZ III to CBZ I during the DCS heating cycle. ICs as immediate release drug delivery systems offer further opportunities for design modified release formulations that may include IC in combination with a polymeric matrix formation compound for additional control of both the drug release profile and drug phase transition.
Publisher:
Relation: https://eprints.ugd.edu.mk/32259/
Identifier: oai:eprints.ugd.edu.mk:32259
Identifier: https://eprints.ugd.edu.mk/32259/1/Cvetkovski%26Drakalska_Mac_Pharm_Bull_2023.pdfIdentifier: Cvetkovski, Aleksandar and Drakalska, Elena (2023) Influence of beta-cyclodextrin on the phase transition in carbamazepine polymorphs. Macedonian pharmaceutical bulletin, 69 (Suppl 1) 189 - 190 (2023). ISSN DOI: 10.33320/maced.pharm.bull.2023.69.03.093
Identifier: http://bulletin.mfd.org.mk/volumes/Volume%2069_3/69_3_093.pdf
