Subject: QC Physics
Year: 2021
Type: Article
Type: NonPeerReviewed
Title: ALGINATE BASED HYDROGELS STABILITY AND THEIR USE FOR CONTROLLED RELEASE OF KETOPROFEN
Author: Iljazi, Beltina
Abstract: Alginate is a biocompatible, non-toxic and biodegradable natural polymer that has found wide application in biomedical science and tissue engineering. Alginate hydrogels are polymers with high water content in their network, which can be used as wound dressings and active substance carriers. Alginate based hydrogels can be obtained in different ways, the most common method to prepare hydrogels from an aqueous alginate solution is to combine the solution with ionic cross-linking agents, such as divalent cations (i.e., Ca2+, Ba2+). The stability of these gels in the physiological environment and the controlled release of active substances from their network are two very important properties that affects the use of these hydrogels for medical purposes. In this research is investigated stability of Ca2+ cross linked alginate hydrogels depending on gel-formation agents amount, in this case CaCO3 and GDL. Also it is followed the controlled release of anti-inflammatory drug, ketoprofen that is loaded inside the alginate hydrogels, for different time intervals. Controlled release is followed in two aqueous media with pH=5.3 and pH=7.0, and analyzed through Ritger-Pepass and Pepass-Sahlin equations. The interpolation of obtained values according to these equations and the calculation of the respective coefficients give information on the factors which control the release in alginate hydrogels.
Publisher: Faculty of Natural Sciences and Mathematics
Relation: https://eprints.unite.edu.mk/731/
Identifier: oai:eprints.unite.edu.mk:731
Identifier: https://eprints.unite.edu.mk/731/1/18.pdfIdentifier: Iljazi, Beltina (2021) ALGINATE BASED HYDROGELS STABILITY AND THEIR USE FOR CONTROLLED RELEASE OF KETOPROFEN. Journal of Natural Sciences and Mathematics of UT, 6 (11-12). pp. 153-161. ISSN 2671-3039
