Year: 2020
Type: Article
Title: Autoimmune thyroiditis after long term gonadotropin- releasing hormone agonist treatment for central precocious puberty: case report
Author: Maja Tankoska
Author: Avdi Murtezani
Author: Konstandina Kuzevska-Maneva
Author: Marina Krstevska-Konstantinova
Abstract: There is a small number of studies that have reported abnormalities in endocrine function after a long-term gonadotropin-releasing hormone agonist (GnRHa) treatment in girls. This treatment is considered as safe and effective by most authors. We report our second case of unusual outcome of long-term GnRHa therapy in a girl with central precocious puberty (CPP) of idiopathic or familial etiology. She has received monthly depot of injections of triptorelin for a time period of 4 years. We have examined thyroid function by measuring serum levels of thyrotropin (TSH), thyroxine (T4), thyroid antibodies and ultrasound of thyroid gland. At the age of 11 years she developed a mild goiter and presented with autoimmune thyroiditis, having elevated thyroid antibodies and ultrasound of thyroid gland typical for Hashimoto thyroiditis. Having in mind these two cases, we suggest a closer monitoring of thyroid function in girls with CPP, before and during therapy with GnRH agonist.
Publisher: Институт за јавно здравје на Р Северна Македонија = Institute of Public Health of R North Macedonia
Relation: Archives of Public Health = Архиви на јавното здравје
Identifier: oai:repository.ukim.mk:20.500.12188/9885
Identifier: http://hdl.handle.net/20.500.12188/9885Identifier: 10.3889/aph.2020.4477
Identifier: https://www.id-press.eu/aph/article/download/4477/4314Identifier: https://www.id-press.eu/aph/article/download/4477/4314Identifier: 12
Identifier: 1
Identifier: 62
Identifier: 65
