Subject: Blood lead level
Subject: aminolevulinic acid dehydratase
Subject: aminolevulinic acid
Subject: biological markers
Subject: Occupational exposure
Subject: toxicity
Year: 2011
Type: Article
Title: Biological Monitoring Among Workers Exposed to Inorganic Lead and Its Compounds
Author: Saso Stoleski
Author: Elisaveta Stikova
Author: Jovanka Karadzinska-Bislimovska
Author: Dragan Mijakoski
Abstract: Objective: To explore the association between lead biomarkers and their deviations in the circumstances of occupational exposure, and influence of life style factors. Material and Methods: We performed cross-sectional study using 60 workers occupationally exposed to lead compared with 60 controls. All examinees were assessed by Questionnaire, and laboratory testing concerning blood lead level (BLL), activity of delta-aminolevulinic acid dehydratase (ALAD) in blood, concentration of delta-aminolevulinic acid (ALA) and coproporphyrin in urine, reticulocytes and erythrocytes with basophilic stippling (EBS). Results: The mean values of BLL and ALA were significantly higher, and mean ALAD activity was significantly lower in lead workers than in controls. Lead workers also had a higher rate of abnormal BLL, ALAD, and ALA, significant for BLL and ALAD. The average BLL values among exposed workers and controls in men were significantly higher. There was strong inverse correlation between distribution of ALAD values in exposed workers due to their BLL values. Significant correlation with mean ALAD values was shown for alcohol consumption, form of compounds, and use of protecting equipment, whereas with mean BLL values was shown for age, gender, exposure duration, smoking, and alcohol consumption. Conclusion: The data confirmed the association between occupational exposure and lead biomarkers abnormalities.
Publisher: ID Design Press
Relation: Macedonian Journal of Medical Sciences
Identifier: oai:repository.ukim.mk:20.500.12188/9732
Identifier: http://hdl.handle.net/20.500.12188/9732Identifier: http://versita.metapress.com/index/RP11670JLVU02R8N.pdfIdentifier: 4
Identifier: 4
