Subject: food allergy
Subject: immunotherapy
Subject: tolerance
Subject: outcome measures
Subject: oral immunotherapy
Subject: immunology
Year: 2020
Type: Article
Title: Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy
Author: Schoos, Ann-Marie Malby
Author: Bullens, Dominique
Author: Chawes, Bo Lund
Author: Costa, Joana
Author: De Vlieger, Liselot
Author: DunnGalvin, Audrey
Author: Epstein, Michelle M
Author: Garssen, Johan
Author: Hilger, Christiane
Author: Knipping, Karen
Author: Kuehn, Annette
Author: Mijakoski, Dragan
Author: Munblit, Daniel
Author: Nekliudov, Nikita A
Author: Ozdemir, Cevdet
Author: Patient, Karine
Author: Peroni, Diego
Author: Stoleski, Sasho
Author: Stylianou, Eva
Author: Tukalj, Mirjana
Author: Verhoeckx, Kitty
Author: Zidarn, Mihaela
Author: van de Veen, Willem
Abstract: IgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is systemic life-threatening reactions. During the last decades, the prevalence of food allergies has significantly increased throughout the world, and considerable efforts have been made to develop curative therapies. Food allergen immunotherapy is a promising therapeutic approach for food allergies that is based on the administration of increasing doses of culprit food extracts, or purified, and sometime modified food allergens. Different routes of administration for food allergen immunotherapy including oral, sublingual, epicutaneous and subcutaneous regimens are being evaluated. Although a wealth of data from clinical food allergen immunotherapy trials has been obtained, a lack of consistency in assessed clinical and immunological outcome measures presents a major hurdle for evaluating these new treatments. Coordinated efforts are needed to establish standardized outcome measures to be applied in food allergy immunotherapy studies, allowing for better harmonization of data and setting the standards for the future research. Several immunological parameters have been measured in food allergen immunotherapy, including allergen-specific immunoglobulin levels, basophil activation, cytokines, and other soluble biomarkers, T cell and B cell responses and skin prick tests. In this review we discuss different immunological parameters and assess their applicability as potential outcome measures for food allergen immunotherapy that may be included in such a standardized set of outcome measures.
Publisher: Frontiers Media SA
Relation: Frontiers in immunology
Identifier: oai:repository.ukim.mk:20.500.12188/9662
Identifier: http://hdl.handle.net/20.500.12188/9662Identifier: 10.3389/fimmu.2020.568598
Identifier: https://www.frontiersin.org/articles/10.3389/fimmu.2020.568598/fullIdentifier: 11
