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Year: 2009

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Type: Article

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Title: The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice

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Author: Ivanovski, Ognen
Author: Nikolov, Igor G
Author: Joki, Nobuhiko
Author: Caudrillier, Axelle
Author: Phan, Olivier
Author: Mentaverri, Romuald
Author: Maizel, Julien
Author: Hamada, Yasuhiro
Author: Nguyen-Khoa, Thao
Author: Fukagawa, Masafumi
Author: Kamel, Said
Author: Lacour, Bernard
Author: Drüeke, Tilman B
Author: Massy, Ziad A

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Abstract: Secondary hyperparathyroidism of chronic kidney disease promotes vascular calcification. Calcimimetics reduce serum parathyroid hormone, calcium (Ca), and phosphorus by calcium-sensing receptor (CaR) activation. Here we examined possible effects of the calcimimetic R-568 (R-568) on the progression of aortic calcification and atherosclerosis in apoE(-/-) mice with chronic renal failure (CRF) and the potential implication of aortic smooth muscle cell CaR.

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Publisher: Elsevier BV

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Relation: Atherosclerosis

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Identifier: oai:repository.ukim.mk:20.500.12188/9604
Identifier: http://hdl.handle.net/20.500.12188/9604
Identifier: 10.1016/j.atherosclerosis.2008.10.043
Identifier: https://api.elsevier.com/content/article/PII:S0021915008007685?httpAccept=text/xml
Identifier: https://api.elsevier.com/content/article/PII:S0021915008007685?httpAccept=text/plain
Identifier: 205
Identifier: 1

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