Year: 2013
Type: Article
Title: Farnesyltransferase inhibitor R115777 protects against vascular disease in uremic mice
Author: Nikolov, Igor G
Author: Joki, Nobuhiko
Author: Galmiche, Antoine
Author: Nguyen-Khoa, Thao
Author: Guerrera, Ida Chiara
Author: Guillonneau, François
Author: Ivanovski, Ognen
Author: Phan, Olivier
Author: Maizel, Julien
Author: Marçon, Frédéric
Author: Benchitrit, Joyce
Author: Lucas, Anthony
Author: Edelman, Aleksander
Author: Lacour, Bernard
Author: Drüeke, Tilman B
Author: Massy, Ziad A
Abstract: Atherosclerosis and vascular calcification are major contributors to cardiovascular morbidity and mortality among chronic kidney disease patients. The mevalonate pathway may play a role in this vascular pathology. Farnesyltransferase inhibitors such as R115777 block one branch of mevalonate pathway. We studied the effects of farnesyltransferase inhibitor R115777 on vascular disease in apolipoprotein E deficient mice with chronic renal failure and on mineral deposition in vitro.
Publisher: Elsevier BV
Relation: Atherosclerosis
Identifier: oai:repository.ukim.mk:20.500.12188/9597
Identifier: http://hdl.handle.net/20.500.12188/9597Identifier: 10.1016/j.atherosclerosis.2013.02.041
Identifier: https://api.elsevier.com/content/article/PII:S0021915013001858?httpAccept=text/xmlIdentifier: https://api.elsevier.com/content/article/PII:S0021915013001858?httpAccept=text/plainIdentifier: 229
Identifier: 1
