Subject: alveolar haemorrhage
Subject: glomerulonephritis
Subject: immune system
Subject: anti-glomerular basement membrane (anti-GBM) antibodies
Subject: Goodpasture syndrome
Year: 2016
Type: Article
Title: Goodpasture Syndrome Diagnosed One Year And A Half after the Appearance of the First Symptoms (Case Report)
Author: Jagoda Stojkovikj
Author: Sead Zejnel
Author: Biljana Gerasimovska
Author: Vesna Gerasimovska
Author: Dragana Stojkovic
Author: Martin Trajkovski
Author: Irina Angelovska
Author: Angela Debreslioska
Author: Smilko Jovanovski
Abstract: BACKGROUND: Goodpasture syndrome was originally described as an association of alveolar haemorrhage and glomerulonephritis. It occurs when the immune system attacks and destroys healthy body tissue. AIM: We are presenting a patient with a clinical picture of pulmonary haemorrhage and glomerulonephritis, which is diagnosed by renal biopsy. CASE PRESENTATION: His illness began a year and a half before being diagnosed. In that period he had occasional exacerbations. He was received at our Clinic in extremely serious condition, and after stabilisation of his medical condition, there was made a biopsy of the kidney. The p-ANCA was 8.93 U/ml (neg < 3, poz > 5 U/ml). Histopathological diagnosis of biopsy of the kidney was: Glomerulonephritis extra capillaries focalis, segmentalis et globalis. Based on this he was diagnosed with Goodpasture syndrome. He received corticosteroid therapy and cyclophosphamide, with good response to treatment, and he is currently in a stable condition, receiving only corticosteroid therapy. CONCLUSION: Goodpasture syndrome is a severe illness caused by the formation of antibodies to the glomerular basement membrane and alveolus with consequential damage to renal and pulmonary function. With current therapy, long-term survival is more than 50%
Publisher: Scientific foundation Spiroski
Relation: Open Access Macedonian Journal of Medical Sciences
Identifier: oai:repository.ukim.mk:20.500.12188/9196
Identifier: http://hdl.handle.net/20.500.12188/9196Identifier: 1857-9655
