Year: 2020
Type: Article
Title: Outcome of Patients With Prior Stroke/Transient Ischemic Attack and Acute Coronary Syndromes
Author: Zhang, Dongfeng
Author: Song, Xiantao
Author: Chen, Yalei
Author: Raposeiras-Roubín, Sergio
Author: Abu-Assi, Emad
Author: Henriques, Jose Paulo Simao
Author: D'Ascenzo, Fabrizio
Author: Saucedo, Jorge
Author: González-Juanatey, José Ramón
Author: Wilton, Stephen B
Author: Kikkert, Wouter J
Author: Nuñez-Gil, Iván
Author: Ariza-Sole, Albert
Author: Alexopoulos, Dimitrios
Author: Liebetrau, Christoph
Author: Kawaji, Tetsuma
Author: Moretti, Claudio
Author: Huczek, Zenon
Author: Nie, Shaoping
Author: Fujii, Toshiharu
Author: Correia, Luis
Author: Kawashiri, Masa-Aki
Author: García-Acuña, José María
Author: Southern, Danielle
Author: Alfonso, Emilio
Author: Terol, Belén
Author: Garay, Alberto
Author: Xanthopoulou, Ioanna
Author: Osman, Neriman
Author: Möllmann, Helge
Author: Shiomi, Hiroki
Author: Giordana, Francesca
Author: Kowara, Michal
Author: Filipiak, Krzysztof
Author: Wang, Xiao
Author: Yan, Yan
Author: Fan, Jingyao
Author: Ikari, Yuji
Author: Nakahashi, Takuya
Author: Sakata, Kenji
Author: Yamagishi, Masakazu
Author: Kalpak, Oliver
Author: Kedev, Sasko
Abstract: The association between prior stroke/transient ischemic attack (TIA) and clinical outcomes in patients with acute coronary syndrome (ACS) has not been well explored. We evaluated the impact of prior stroke/TIA on this specific patient population. We conducted an international multicenter study including 15 401 patients with ACS from the Bleeding Complications in a Multicenter Registry of Patients Discharged With Diagnosis of Acute Coronary Syndrome registry. They were divided into 2 groups: patients with and without prior stroke/TIA. The primary end point was death at 1-year follow-up. Prior stroke/TIA was associated with higher rate of 1-year death (8.7% vs 3.4%; P < .001). It was an independent predictor of 1-year death even after adjustment for confounding variables (odds ratio, 1.705; 95% confidence interval, 1.046-2.778; P = .032). Besides, patients with prior stroke/TIA had significantly increased 1-year reinfarction (5.6% vs 3.8%, P = .015), in-hospital bleeding (8.7% vs 5.8%, P < .001), and 1-year bleeding (5.2% vs 3.0%, P < .001). No difference of antithrombotic therapies or dual antiplatelet therapy (DAPT) types on outcomes was observed in patients with prior stroke/TIA. Prior stroke/TIA was associated with higher 1-year death for patients with ACS who underwent percutaneous coronary intervention. No benefits or harms were observed with different antithrombotic therapies or DAPT types in these patients.
Publisher: SAGE Publications
Relation: Angiology
Identifier: oai:repository.ukim.mk:20.500.12188/8996
Identifier: http://hdl.handle.net/20.500.12188/8996Identifier: 10.1177/0003319719889524
Identifier: http://journals.sagepub.com/doi/pdf/10.1177/0003319719889524Identifier: http://journals.sagepub.com/doi/full-xml/10.1177/0003319719889524Identifier: http://journals.sagepub.com/doi/pdf/10.1177/0003319719889524Identifier: 71
Identifier: 4
