Subject: epidural analgesia,
Subject: remifentanil,
Subject: side effects
Year: 2019
Type: Article
Title: Side Effects of Intravenous Patient-Controlled Analgesia with Remifentanil Compared with Intermittent Epidural Bolus for Labour Analgesia - A Randomized Controlled Trial
Author: Dafina Karadjova
Author: Mirjana Shosholcheva
Author: Еmilija Ivanov
Author: Аtanas Sivevski
Author: Ivo Kjaev
Author: Andrijan Kartalov
Author: Biljana Kuzmanovska
Author: Rosa Spasova
Author: Goran Kocovski
Author: Irena Aleksiovska-Papestiev
Abstract: Introduction: Epidural analgesia is considered a gold standard in obstetric anaesthesia and analgesia. However, in situation when it is contraindicated, unwanted by the patient or simply unavailable, remifentanil can be an excellent alternative. The goal of our study is to analyse the side effects of intravenous patient-controlled analgesia (IV PCA) with remifentanil compared with epidural analgesia during delivery. Material and methods: This study included 155 pregnant women in term for birth, divided into 2 groups: a remifentanil group (RG), and an epidural group (EG). Patients in the RG received intravenous PCA with remifentanil, while patients in the ЕG received epidural analgesia with programmed intermittent bolus dosing. Our primary outcome was maternal safety; the secondary outcome was neonatal safety. Results: The results present a significantly lower SaO2 value of the parturients in the RG (96.95 ± 1.4 vs 98.22 ± 0.6), and a significantly higher respiratory rate per minute in the EG at all time points after the onset of analgesia (20.85 ± 1.4 vs 18.67 ± 0.9). There was more frequent sedation, nausea and vomiting in the RG, while in the EG there was a more elevated temperature, itching and irregularities in the CTG record. Regarding the newborn, there was no significant difference between the two groups in the Apgar scores, pH, pCO2, pO2, and bicarbonate, while there was a significantly lower value of the base excess in the RG group. Conclusion: PCA with remifentanil is safe for the mother, foetus and the newborn, with minimal side effects. Continuous respiratory monitoring, oxygen supply and following of all consensus recommendations are mandatory.
Publisher: Macedonian Academy of Sciences and Arts / Walter de Gruyter GmbH
Relation: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
Identifier: oai:repository.ukim.mk:20.500.12188/8813
Identifier: 1857-9345
Identifier: http://hdl.handle.net/20.500.12188/8813Identifier: 10.2478/prilozi-2020-0009
Identifier: 40
Identifier: 3
Identifier: 99
