Year: 2019
Type: Article
Title: Importance of 6-Thioguanine Nucleotide Metabolite Monitoring in Inflammatory Bowel Disease Patients Treated with Azathioprine
Author: Pavlovska, Kristina
Author: Petrushevska, Marija
Author: Kalina Gjorgjievska
Author: Zendelovska, Dragica
Author: Ribarska, Jasmina Tonic
Author: Kikerkov, Igor
Author: Labachevska Gjatovska, Liljana
Author: Atanasovska, Emilija
Abstract: The active metabolite of azathioprine, 6-thioguanine nucleotide (6-TGN) is the main component responsible for the immunosuppressive effect in treatment of inflammatory bowel disease (IBD). The aim of this study was to assess the correlation between the concentration of 6-thioguanine nucleotide and disease activity, azathioprine-related adverse effects and time duration of treatment in patients with inflammatory bowel disease. Thirty-four patients were included in this study. Type of disease, gender, time duration of therapy and adverse effects were recorded. Metabolite concentration was determined by high performance liquid chromatography. Twenty-one percent of patients have experienced an adverse effect, with leucocytopenia most commonly occurring (42.9%). More adverse effects were registered when patients were treated with azathioprine in a period of less than 3 months in comparison to the group of patients that have been under therapy between 3-12 months and more than 12 months (p˂0.05). Most of the patients that presented any adverse effect had high 6-TGN concentration (>450 pmol/8x108 Er). The mean value of 6-TGN metabolite concentration in IBD patients treated with azathioprine was 437.46 pmol/8x108 Er ± 198.82 pmol/8x108. The time duration of azathioprine treatment did not have any significant impact on the achieved 6-TGN concentration (p>0.05).Twenty patients (58.9%) had achieved remission after therapy initiation with azathioprine. More alertness is recommended to clinicians towards patients in the first 3 months of the therapy. Our study demonstrated that higher 6-TGN concentration is associated with azathioprine toxicity.
Publisher: Macedonian Academy of Sciences and Arts / Walter de Gruyter GmbH
Relation: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
Identifier: oai:repository.ukim.mk:20.500.12188/8589
Identifier: http://hdl.handle.net/20.500.12188/8589Identifier: 10.2478/prilozi-2019-0006
Identifier: http://content.sciendo.com/view/journals/prilozi/40/1/article-p73.xmlIdentifier: http://www.degruyter.com/view/j/prilozi.2019.40.issue-1/prilozi-2019-0006/prilozi-2019-0006.pdfIdentifier: 40
Identifier: 1
Identifier: 73
Identifier: 79
