Subject: heroin addiction,
Subject: oxidative stress,
Subject: free radicals,
Subject: lipid peroxidation,
Subject: total antioxidant capacity
Year: 2007
Type: Article
Title: Prooxidative/antioxidative Homeostasis in Heroin Addiction and Detoxification
Author: Pereska Z
Author: Dejanova, Beti
Author: Bozinovska C
Author: Petkovska, Lidija
Abstract: Background: Long-term heroin abuse is related to pathological changes in many organs mediated by oxidative stress (OS). Objectives: Estimation of systemic OS and antioxidant capacity in heroin addiction and detoxification provides information about prooxidant/antioxidant homeostasis in heroin misuse and need for antioxidant supplementation. Methods: OS was evaluated by the measurement of plasma reactive oxygen metabolites using spectrophotometric method and plasma lipid peroxidation by its end product--malondyaldehyd using Tiobarbituric Acid Reactions Substances method. The extracellular antioxidant capacity was estimated using OXY-adsorbent test. Results: This cross-sectional study includes 68 patients: 46 heroin addicts (20 patients on chronic heroin abuse, 19 patients on conventional method of detoxification and 7 patients on opioid antagonist--naltrexone (and 22 patients as a control) group. Increased OS was found in the heroin group (d-ROMs 349.3 +/- 102.2 UCarr, MDA 4.0 +/- 0.4 micromol/L) compared to the group on detoxification (d-ROMs 230.2 +/- 96.4 UCarr; MDA 3.6 +/- 0.3 micromol/L) and control group (d-ROMs 264.1 +/- 30.9 UCarr; MDA 3.7 +/- 0.2 micromol/L). TAC was decreased in the heroin group (324.5 +/- 75.0 micromol HClO/ml) and restored during conventional detoxification (371.8 +/- 25.1 micromol HClO/ml), but not completely in the group with naltrexone treatment (335.6 +/- 16.9 micromol HClO/ml) compared with controls (395.4 +/- 35.6 micromol HClO/ml). Conclusion: Long-term heroin abuse stimulates a progressive systemic oxidative stress which increases the extracellular antioxidants consumption and develops conditions for chronic heroin toxicity
Publisher: SAP-Slovak Academic Press s.r.o.
Relation: Bratislavské lekárske listy = Bratislava Medical Journal
Identifier: oai:repository.ukim.mk:20.500.12188/8243
Identifier: http://hdl.handle.net/20.500.12188/8243
