Subject: dyslipidemia,
Subject: lipoprotein (a),
Subject: statins,
Subject: extended-release niacin (ERN),
Subject: micronized fenofibrate
Year: 2016
Type: Article
Title: Effects of Rosuvastatin Versus Atorvastatin, Alone or in Combination, on Lipoprotein (a): A Single-Center Study
Author: Vavlukis, Marija
Author: Mladenovska, Kristina
Author: Daka, Arlinda
Author: Dimovski, Aleksandar
Author: Domazetovska, Saska
Author: Kuzmanovska, Sonja
Author: Kedev, Sasko
Abstract: Background: There are little evidences about the therapeutic efficacy of different lipid-lowering agents in the reduction of elevated lipoprotein(a) [Lp(a)]. Objective: testing the effect of different lipid-lowering agents on elevated Lp(a). Methods: prospective interventional study performed in patients with CAD, or high CAD risk, with Lp(a), >50 mg/dL. Lp(a), total cholesterol (C), HDL-C, LDL-C, triglycerides (TGs), apolipoprotein (Apo) A1, Apo B, enzymes of myocyte and hepatic injury were comparatively analyzed between 4 lipid-lowering strategies: rosuvastatin (R group) 40 mg, atorvastatin (A group) 80 mg, atorvastatin 40 mg add-on micronized fenofibrate (A+F group), and atorvastatin 40 mg add-on 1 g extended-release niacin (A+ERN group). Comparison was made for their therapeutic efficacy on Lp(a), and safety. Results: 87 patients with mean Lp(a) 94.6 ± 39.6 mg/dL were analyzed. Groups: 25 patients in the R, 22 in the A, 20 in the A+F and 20 in A+ERN group. Significant reduction in all lipid fractions in all treatment groups was reported after 6 months. The average reduction of Lp(a) was 15.9 ± 21.0 mg/dL, with: 18.2 ± 24.8 (P = 0.001) in the R group, 17.3 ± 10.4 (P = 0.001) in A+F, 19.5 ± 10.9 (P = 0.001) in A+ERN and the lowest in the A group (11.24 ± 22.91, P = 0.032). No adverse effects were observed in any of the treatment groups. Conclusions: When compared with atorvastatin, it seems that rosuvastatin can achieve more significant decrease of Lp(a).The efficacy of the second one can be increased by adding fibrate or ERN.
Publisher: aop.sagepub.com
Relation: /
Identifier: oai:repository.ukim.mk:20.500.12188/7335
Identifier: http://hdl.handle.net/20.500.12188/7335Identifier: DOI: 10.1177/1060028016652415
Identifier: 50
Identifier: 8
