Subject: COVID-19
Subject: vitamin D
Subject: oxidative stress
Subject: plasma peroxides
Subject: disease severity
Subject: antioxidants
Subject: inflammation
Year: 2021
Type: Article
Title: Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19
Author: Atanasovska, Emilija
Author: Petrushevska, Marija
Author: Zendelovska, Dragica
Author: Spasovska, Katerina
Author: Stevanovikj, Milena
Author: Kasapinova, Katerina
Author: Gjorgjievska, Kalina
Author: Labachevski, Nikola
Abstract: Background: COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in hospitalized COVID-19 patients. Methods: Vitamin D levels were measured in 33 patients with COVID-19. The total antioxidant power and plasma peroxides were determined in serum. Results: Severe COVID-19 patients have lower vitamin D levels (18.39 ± 2.29 ng/mL vs. 28.47 ± 3.05 ng/mL, p < .05) and higher oxidative stress compared to the moderate group. When divided according to serum vitamin D levels, significantly higher values of LDH (604.8 ± 76.98 IU/mL vs. 261.57 ± 47.33 IU/mL) and D-dimer (5978 ± 2028ng/mL vs. 977.7 ± 172 ng/mL) were obtained in the group with vitamin D below 30 ng/mL, followed with significantly higher levels of plasma peroxides (d-ROMs: 414.9 ± 15.82 U.Carr vs. 352.4 ± 18.77 U.Carr; p < .05) and oxidative stress index (OSI: 92.25 ± 6.60 vs. 51.89 ± 6.45; p < .001). Conclusion: The presented data provide a justification to consider vitamin D as an important factor that could ameliorate disease severity through its anti-inflammatory and antioxidant effects.
Publisher: TAYLOR & FRANCIS LTD
Relation: Redox Report
Identifier: oai:repository.ukim.mk:20.500.12188/30142
Identifier: 26(1):184-189. doi: 10.1080/13510002.2021.1999126. PMID: 34727009; PMCID: PMC8567917
Identifier: http://hdl.handle.net/20.500.12188/30142
