Subject: Fluorine-18
Subject: Radiosynthesis
Subject: Yield
Subject: Radioactivity
Subject: Pitfalls
Year: 2023
Type: Article
Title: Evaluation of factors with potential influence on [18F]FDG radiochemical synthesis yield
Author: Chochevska, Maja
Author: Velichkovska, Maja
Author: Atanasova Lazareva, Marija
Author: Kolevska, Katerina
Author: Jolevski, Filip
Author: Razmoska, Jasmina
Author: Filipovski, Zlatko
Author: Nikolovski, Sasho
Author: Zdraveska Kochovska, Marina
Author: Ugrinska, Ana
Abstract: [18F]FDG radiopharmaceutical production is performed with automatic synthesis modules, which enables to carry out the production process safely, reliably and reproducibly. This study aimed to investigate the factors which may influence and give inconsistent radiochemical synthesis yield, as well as common pitfalls in the synthesis process which can occur. We evaluated more than 500 batches in the overall study. The results confirmed that irradiation parameter affect the production yield of the final product, also transport capillary capability and some synthesis factors have an impact on [18F]FDG radiochemical synthesis yield.
Publisher: Elsevier BV
Relation: Applied Radiation and Isotopes
Identifier: oai:repository.ukim.mk:20.500.12188/30125
Identifier: http://hdl.handle.net/20.500.12188/30125Identifier: 10.1016/j.apradiso.2023.110900
Identifier: https://api.elsevier.com/content/article/PII:S0969804323002531?httpAccept=text/xmlIdentifier: https://api.elsevier.com/content/article/PII:S0969804323002531?httpAccept=text/plainIdentifier: 199
Identifier: 110900
