Subject: hyperthyroidism
Subject: thyroid dysfunction
Subject: thyroid hormones
Subject: Wistar rats
Year: 2023
Type: Article
Title: EXPERIMENTAL ANIMAL MODEL OF THYROID DYSFYNCTION- HYPERTHYROIDISM
Author: Stojkovska, Natasha
Author: Manevska, Nevena
Author: Makazlieva, Tanja
Author: Tasheva, Ljubica
Author: Tripunoski, Toni
Author: Stojanoski, Sinisha
Author: Paunkoska, Anamarija
Author: Kostadinova Petrova, Irena
Abstract: To establish an experimental animal model of impaired function of the thyroid gland – hyperthyroidism. Thyroid dysfunction (hypothyroidism, hyperthyroidism) is classified in the group of non-communicable diseases with high incidence and prevalence. The disturbed function of the thyroid gland reflects in the metabolic processes of organs, tissues and at cellular level. Twenty Wistar rats (10 males - 350 ± 40 gr and 10 females - 320 ± 40 gr), with an average age of 7 months, were analyzed in the period of 2 months (treated for 1 month with pharmacological doses of L-Thyroxin 15mg / 100g body mass in the drinking water and 1 following month without treatment). The second group of 10 Wistar rats - (5 males and 5 females) did not recieve L-Thyroxin and this was the control group used to obtain normal morphometric and biochemical parameters. Between the mean values of FT4 and FT3 at the beginning, at the intersection and at the end of the study, there were statistically significant differences with increased levels of thyroid hormones at the cross section and no statistically significant difference of thyroid hormone levels between the beginning and the end of the examination in the group of rats treated with L-Thyroxin. No statistically significant differences were detected in the control group of rats. Experimental animal model of impaired function of the thyroid gland – hyperthyroidism using Wistar rats as subjects was successfully established.
Publisher: Macedonian Association of Anatomists and Morphologists
Relation: JMS = Journal of Morphological Sciences
Identifier: oai:repository.ukim.mk:20.500.12188/29957
Identifier: http://hdl.handle.net/20.500.12188/29957Identifier: 10.55302/jms2362016s
Identifier: 6
Identifier: 2
Identifier: 16
Identifier: 28
