Subject: bladder cancer
Subject: PD-L1 gene expression
Subject: polymorphisms rs861539
Subject: biomarker
Year: 2023
Type: Article
Title: CORRELATION OF PD-L1 GENE EXPRESSION WITH GRADE OF THE URINARY BLADDER CANCER
Author: Stankov, Viktor
Author: Stankov, Oliver
Author: Dohchev, Sasho
Author: Stavridis, Sotir
Author: Ivanovski, Ognen
Author: Janchulev, Josif
Author: Ambardjieva, Martina
Author: Gavrilovska-Brzanov, Aleksandra
Author: Panov, Sasho
Author: Saidi, Skender
Abstract: Abstract Introduction. Bladder cancer (BC) ranks fourth in the prevalence of malignancies in developed countries and is the eighth leading cause of cancer-related mortality in men. PD-L1, known for its role in inhibiting immune responses against malignant cells, has garnered significant attention in BC research. Methods. This study, comprising 45 patients with histopathologically confirmed urothelial carcinoma of the urinary bladder, analyzed the connection between histological grade and PD-L1 gene expression. The patient cohort was divided into 31 classified as low-grade and 14 as high-grade, with gender and age distribution well-balanced across the groups. PD-L1 expression was notably higher in the high-grade group (p=0.005), showing its potential clinical relevance as a biomarker. Results. Univariate logistic analysis revealed a robust correlation between histological grade and PDL1 expression, with high-grade patients exhibiting a 7.227-fold higher likelihood of increased PD-L1 expression. A predictive model for grade determination demonstrated commendable performance, boasting an area under the curve (AUC) of 0.788. Conclusion. These findings provide compelling evidence of a strong association between PD-L1 gene expression and the histological grade of bladder cancer. PD-L1 emerges as a potential biomarker, shedding light on a disease pathological grade, offering a significant clinical value for precise prognosis, and guiding tailored treatment strategies. These insights hold promise for improved disease management and patient outcomes.
Publisher: Македонско лекарско друштво = Macedonian medical association
Relation: Македонски Медицински Преглед = Macedonian Medical Review
Identifier: oai:repository.ukim.mk:20.500.12188/29467
Identifier: http://hdl.handle.net/20.500.12188/29467
