Year: 2023
Type: Article
Title: If You're Not Confused, You're Not Paying Attention: Ochrobactrum Is Not Brucella
Author: Moreno, Edgardo
Author: Middlebrook, Earl A
Author: Altamirano-Silva, Pamela
Author: Al Dahouk, Sascha
Author: Araj, George F
Author: Arce-Gorvel, Vilma
Author: Arenas-Gamboa, Ángela
Author: Ariza, Javier
Author: Barquero-Calvo, Elías
Author: Battelli, Giorgio
Author: Bertu, Wilson J
Author: Blasco, José María
Author: Bosilkovski, Mile
Author: Cadmus, Simeon
Author: Caswell, Clayton C
Author: Celli, Jean
Author: Chacón-Díaz, Carlos
Author: Chaves-Olarte, Esteban
Author: Comerci, Diego J
Author: Conde-Álvarez, Raquel
Author: Cook, Elizabeth
Author: Cravero, Silvio
Author: Dadar, Maryam
Author: De Boelle, Xavier
Author: De Massis, Fabrizio
Author: Díaz, Ramón
Author: Escobar, Gabriela I
Author: Fernández-Lago, Luis
Author: Ficht, Thomas A
Author: Foster, Jeffrey T
Author: Garin-Bastuji, Bruno
Author: Godfroid, Jacques
Author: Gorvel, Jean-Pierre
Author: Güler, Leyla
Author: Erdenliğ-Gürbilek, Sevil
Author: Gusi, Amayel M
Author: Guzmán-Verri, Caterina
Author: Hai, Jiang
Author: Hernández-Mora, Gabriela
Author: Iriarte, Maite
Author: Jacob, Nestor R
Author: Keriel, Anne
Author: Khames, Maamar
Author: Köhler, Stephan
Author: Letesson, Jean-Jacques
Author: Loperena-Barber, Maite
Author: López-Goñi, Ignacio
Author: McGiven, John
Author: Melzer, Falk
Author: Mora-Cartin, Ricardo
Author: Moran-Gilad, Jacob
Author: Muñoz, Pilar M
Author: Neubauer, Heinrich
Author: O'Callaghan, David
Author: Ocholi, Reuben
Author: Oñate, Ángel
Author: Pandey, Piyush
Author: Pappas, Georgios
Author: Pembroke, J Tony
Author: Roop, Martin
Author: Ruiz-Villalonos, Nazaret
Author: Ryan, Michael P
Author: Salcedo, Suzana P
Author: Salvador-Bescós, Miriam
Author: Sangari, Félix J
Author: de Lima Santos, Renato
Author: Seimenis, Aristarchos
Author: Splitter, Gary
Author: Suárez-Esquivel, Marcela
Author: Tabbaa, Darem
Author: Trangoni, Marcos David
Author: Tsolis, Renee M
Author: Vizcaíno, Nieves
Author: Wareth, Gamal
Author: Welburn, Susan C
Author: Whatmore, Adrian
Author: Zúñiga-Ripa, Amaia
Author: Moriyón, Ignacio
Abstract: Bacteria of the genus Brucella are facultative intracellular parasites that cause brucellosis, a severe animal and human disease. Recently, a group of taxonomists merged the brucellae with the primarily free-living, phylogenetically related Ochrobactrum spp. in the genus Brucella. This change, founded only on global genomic analysis and the fortuitous isolation of some opportunistic Ochrobactrum spp. from medically compromised patients, has been automatically included in culture collections and databases. We argue that clinical and environmental microbiologists should not accept this nomenclature, and we advise against its use because (i) it was presented without in-depth phylogenetic analyses and did not consider alternative taxonomic solutions; (ii) it was launched without the input of experts in brucellosis or Ochrobactrum; (iii) it applies a non-consensus genus concept that disregards taxonomically relevant differences in structure, physiology, population structure, core-pangenome assemblies, genome structure, genomic traits, clinical features, treatment, prevention, diagnosis, genus description rules, and, above all, pathogenicity; and (iv) placing these two bacterial groups in the same genus creates risks for veterinarians, medical doctors, clinical laboratories, health authorities, and legislators who deal with brucellosis, a disease that is particularly relevant in low- and middle-income countries. Based on all this information, we urge microbiologists, bacterial collections, genomic databases, journals, and public health boards to keep the Brucella and Ochrobactrum genera separate to avoid further bewilderment and harm.
Publisher: American Society for Microbiology
Relation: Journal of clinical microbiology
Identifier: oai:repository.ukim.mk:20.500.12188/29356
Identifier: http://hdl.handle.net/20.500.12188/29356Identifier: 10.1128/jcm.00438-23
Identifier: https://journals.asm.org/doi/pdf/10.1128/jcm.00438-23Identifier: https://journals.asm.org/doi/pdf/10.1128/jcm.00438-23Identifier: 61
Identifier: 8
