Subject: CD44
Subject: HCC
Subject: immunohistochemistry
Subject: T status
Subject: survival
Year: 2020
Type: Article
Title: Immunohistochemical expression of CD44 in patients with hepatocellular carcinoma
Author: Nikolova, Dafina
Author: Chaloska ivanova, Viktorija
Author: Jovanovikj, Rubens
Author: Janevska, Vesna
Author: Nikolovska Trpchevska, Emilija
Author: Volkanovska, Anche
Abstract: Introduction: CD44, a transmembrane glycoprotein with a role in cell-cell and cell-matrix interactions and one of the stem cell markers, is considered to participate in progression and prognosis of hepatocellular carcinoma (HCC), which makes it a potential prognostic marker and therapeutic target. We aimed to evaluate immunoexpression of CD44 in tumor and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathological data in order to determine its prognostic value in patients from the Republic of North Macedonia. Material and Methods: Presence of the immunosignal and the percentage of CD44+ tumor cells at the whole tumor tissue sample and adjacent cirrhotic liver tissue were semi-quantitatively determined. The immunohistochemistry results were correlated to B and C hepatitis, tumor dimensions, enlarged lymph nodes, T status, differentiation (G), microvascular invasion, and survival. Results: We found a significant difference in CD44 expression between tumor and non-tumor liver tissue (p < 0.000) and significantly higher CD44 expression was also found in T4 tumors in comparison with T1 tumors (p < 0.01). Conclusion: Expression of CD44 was significantly higher in tumor in comparison to non-tumor tissue and was significantly associated to T4 local tumor growth, making it a potential prognostic marker and therapeutic target.
Publisher: Macedonian Association of Anatomists and Morphologists
Relation: JMS - Journal of Morphological Sciences
Identifier: oai:repository.ukim.mk:20.500.12188/29214
Identifier: http://hdl.handle.net/20.500.12188/29214
