Subject: human papillomavirus
Subject: squamous cell abnormalities
Subject: uterine cervix
Year: 2019
Type: Article
Title: Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix
Author: Dabeski, Drage
Author: Dabeski, Ana
Author: Antovska, Vesna
Author: Trajanova, Milka
Author: Todorovska, Irena
Author: Sima, Aneta
Abstract: Background: Human papillomavirus infections are one of the most common sexually transmitted infections with viral aetiology. The aim of the study was to confirm the existence of an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix. Methods: Cohort study, conducted in the period from January 2017 to June 2018 of 768 sexually active women, age groups of 20 to 59 years, divided into two groups: examined and control, who came to their annual gynaecological exam at University Clinic for Gynaecology and Obstetrics in Skopje. In all patients was done human papillomavirus-deoxyribonucleic testing. Human papillomavirus detection and typing was done using a polymerase chain reaction and reverse hybridisation. Results: Data analysis showed an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix (p=0.00001). Human papillomavirus infection was detected in 22.91% of all patients, in 75.00% of patients with abnormal cervical cytology and in 12.50% of patients with normal cervical cytology. A single human papillomavirus infection was detected in 13.67% of all patients (in 59.66% of human papillomavirus positive patients). Mixed human papillomavirus infection was detected in 9.24% of all patients (in 40.34% of human papillomavirus positive patients). Human papillomavirus type 16 was the most common genotype with 40.91%. Conclusion: This study confirmed that there is an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix and the young population under the age of 30 years is the most affected.
Publisher: Centre for Evaluation in Education and Science
Relation: Scripta Medica
Identifier: oai:repository.ukim.mk:20.500.12188/28764
Identifier: http://hdl.handle.net/20.500.12188/28764
