Subject: endothelial dysfunction
Subject: hypertensive disorders of pregnancy
Subject: gestational hypertension
Subject: preeclampsia
Subject: HELLP Syndrome
Subject: acute fatty liver of pregnancy
Year: 2023
Type: Article
Title: The Role of Endothelial Dysfunction in the Pathogenesis of Pregnancy-Related Pathological Conditions: A Review
Author: Curakova Ristovska, Elena
Author: Genadieva Dimitrova, Magdalena
Author: Todorovska, Beti
Author: Milivojevic, Vladimir
Author: Rankovic, Ivan
Author: Samardjiski, Igor
Author: Bojadzioska, Maja
Abstract: In the recent decades, endothelial dysfunction (ED) has been recognized as a significant contributing factor in the pathogenesis of many pathological conditions. In interaction with atherosclerosis, hypercholesterolemia, and hypertension, ED plays a crucial role in the pathogenesis of coronary artery disease, chronic renal disease, and microvascular complications in diabetes mellitus. Although ED plays a significant role in the pathogenesis of several pregnancy-related disorders such as preeclampsia, HELLP syndrome, fetal growth restriction, and gestational diabetes mellitus, the exact pathogenetic mechanisms are still a matter of debate. The increased prevalence of these entities in patients with preexisting vascular diseases highlights the essential pathological role of the preexisting ED in these patients. The abnormal uteroplacental circulation and the release of soluble factors from the ischemic placenta into the maternal bloodstream are the main causes of the maternal ED underlying the characteristic preeclamptic phenotype. Besides the increased risk for maternal and fetal poor outcomes, the preexisting ED also increases the risk of development of future cardiovascular diseases in these patients. This study aimed to look deeper into the role of ED in the pathogenesis of several pregnancy-related hypertensive and liver diseases. Hopefully, it could contribute to improvement of the awareness, knowledge, and management of these conditions and also to the reduction of the adverse outcomes and additional long-term cardiovascular complications.
Publisher: Walter de Gruyter GmbH
Relation: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
Identifier: oai:repository.ukim.mk:20.500.12188/28370
Identifier: http://hdl.handle.net/20.500.12188/28370Identifier: 10.2478/prilozi-2023-0032
Identifier: https://www.sciendo.com/pdf/10.2478/prilozi-2023-0032Identifier: 44
Identifier: 2
