Subject: Diclofenac sodium, PEO-PPO-PEO Ophthalmic micelles, FTIR, DSC, NMR, D-optimal design model, Mucus adhesion and permeation
Year: 2022
Type: Journal Article
Title: Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour
Author: Koummich, Sarra Aicha
Author: Zoukh, Ikram Mustapha
Author: Gorachinov, Filip
Author: Geskovski, Nikola
Author: Makreski, Petre
Author: Dodov, Marija Glavas
Author: Goracinova, Katerina
Abstract: TY - JOUR AU - Koummich, Sarra Aicha AU - Zoukh, Ikram Mustapha AU - Gorachinov, Filip AU - Geskovski, Nikola AU - Makreski, Petre AU - Dodov, Marija Glavas AU - Goracinova, Katerina PY - 2022 DA - 2022/06/01 TI - Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour JO - Drug Delivery and Translational Research SP - 1488 EP - 1507 VL - 12 IS - 6 AB - Diclofenac sodium 0.1% is a commonly used NSAID with well-documented clinical efficacy in reducing postoperative inflammation; however, its corneal tolerability and ophthalmic tissue bioavailability require further improvement. Advanced micellar delivery systems composed of block-copolymers and chitosan showing fine balance between the mucoadhesion and mucus permeation, capable to slip through the mucus barrier and adhere to the epithelial ocular surface, may be used to tackle both challenges. The aggregation behaviour of the block-copolymers in the presence of different additives will dramatically influence the quality attributes like particle size, particle size distribution, drug-polymer interaction, zeta potential, drug incorporation, important for the delicate balance among mucoadhesion and permeation, as well as safety and efficacy of the ophthalmic micelles. Therefore, quality by design approach and D-optimal experimental design model were used to create a pool of useful data for the influence of chitosan and the formulation factors on the block copolymer’s aggregation behaviour during the development and optimization of Diclofenac loaded Chitosan/Lutrol F127 or F68 micelles. Particle size, polydispersity index, dissolution rate, FTIR and DSC studies, NMR spectroscopy, cytotoxicity, mucoadhesivity, mucus permeation studies, and bioadhesivity were assessed as critical quality attributes. FTIR and DSC studies pointed to the chaotropic effect of chitosan during the micelle aggregation. Mainly, Pluronic F68 micellization behaviour was more dramatically affected by the presence of chitosan, and self-aggregation into larger micelles with high polydispersity index was favoured at higher chitosan concentration. The optimized formulation with highest potential for ophthalmic delivery of diclofenac sodium, good cytotoxicity profile, delicate balance of the mucoadhesivity, and mucus permeation was in the design space of Chitosan/Lutrol F127 micelles. SN - 2190-3948 UR - https://doi.org/10.1007/s13346-021-01030-4 DO - 10.1007/s13346-021-01030-4 ID - Koummich2022 ER -
Publisher: Springer Science and Business Media LLC
Relation: Drug delivery systems for improved ophthalmic delivery, QUST-1-CPH2020-8, Qatar University
Identifier: oai:repository.ukim.mk:20.500.12188/27303
Identifier: Koummich, S.A., Zoukh, I.M., Gorachinov, F. et al. Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour. Drug Deliv. and Transl. Res. 12, 1488–1507 (2022). https://doi.org/10.1007/s13346-021-01030-4Identifier: http://hdl.handle.net/20.500.12188/27303Identifier: 10.1007/s13346-021-01030-4
Identifier: https://link.springer.com/content/pdf/10.1007/s13346-021-01030-4.pdfIdentifier: https://link.springer.com/article/10.1007/s13346-021-01030-4/fulltext.htmlIdentifier: https://link.springer.com/content/pdf/10.1007/s13346-021-01030-4.pdfIdentifier: 12
Identifier: 6
