Subject: acute heart failure
Subject: outcomes
Subject: sex differences
Year: 2023
Type: Article
Title: Sex Differences in Heart Failure Following Acute Coronary Syndromes
Author: Cenko, Edina
Author: Manfrini, Olivia
Author: Yoon, Jinsung
Author: van der Schaar, Mihaela
Author: Bergami, Maria
Author: Vasiljevic, Zorana
Author: Mendieta, Guiomar
Author: Stankovic, Goran
Author: Vavlukis, Marija
Author: Kedev Sasko
Author: Miličić, Davor
Author: Badimon, Lina
Author: Bugiardini, Raffaele
Abstract: BACKGROUND There have been conflicting reports regarding outcomes in women presenting with acute coronary syndrome (ACS).OBJECTIVES The objective of the study was to examine sex-specific differences in 30-day mortality in patients with ACS and acute heart failure (HF) at the time of presentation.METHODS This was a retrospective study of patients included in the International Survey of Acute Coronary Syndromes (ISACS Archives-NCT04008173). Acute HF was defined as Killip classes $2. Participants were stratified according to ACSpresentation: ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation ACS (NSTE-ACS). Differences in 30-day mortality and acute HF presentation at admission between sexes were examined using inverse propensity weighting based on the propensity score. Estimates were compared by test of interaction on the log scale. RESULTS A total of 87,812 patients were included, of whom 30,922 (35.2%) were women. Mortality was higher in women compared with men in those presenting with STEMI (risk ratio (RR): 1.65; 95% CI: 1.56-1.73) and NSTE-ACS (RR:1.18; 95% CI: 1.09-1.28; P interaction < 0.001). Acute HF was more common in women when compared to men with STEMI(RR: 1.24; 95% CI: 1.20-1.29) but not in those with NSTE-ACS (RR: 1.02; 95% CI: 0.97-1.08) (P interaction < 0.001). The presence of acute HF increased the risk of mortality for both sexes (odds ratio: 6.60; 95% CI: 6.25-6.98).CONCLUSIONS In patients presenting with ACS, mortality is higher in women. The presence of acute HF at hospital presentation increases the risk of mortality in both sexes. Women with STEMI are more likely to present with acute HFand this may, in part, explain sex differences in mortality. These findings may be helpful to improve sex-specific personalized risk stratification. (JACC Adv 2023;-:100294) © 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open-access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) (14) (PDF) Sex Differences in Heart Failure Following Acute Coronary Syndromes. Available from: https://www.researchgate.net/publication/370306869_Sex_Differences_in_Heart_Failure_Following_Acute_Coronary_Syndromes [accessed Jun 23, 2023].
Publisher: Elsevier BV
Relation: ISACS_CT Registry
Identifier: oai:repository.ukim.mk:20.500.12188/26934
Identifier: dina Cenko, Olivia Manfrini, Jinsung Yoon, Mihaela van der Schaar, Maria Bergami, Zorana Vasiljevic, Guiomar Menddina Cenko, Olivia Manfrini, Jinsung Yoon, Mihaela van der Schaar, Maria Bergami, Zorana Vasiljevic, Guiomar Mendieta, Goran Stankovic, Marija Vavlukis, Sasko Kedev, Davor Miličić, Lina Badimon, Raffaele Bugiardini, Sex Differences in Heart Failure Following Acute Coronary Syndromes, JACC: Advances, Volume 2, Issue 3, 2023, 100294, ISSN 2772-963X, https://doi.org/10.1016/j.jacadv.2023.100294. (https://www.sciencedirect.com/science/article/pii/S2772963X23000492)Identifier: http://hdl.handle.net/20.500.12188/26934Identifier: 10.1016/j.jacadv.2023.100294
Identifier: https://api.elsevier.com/content/article/PII:S2772963X23000492?httpAccept=text/xmlIdentifier: https://api.elsevier.com/content/article/PII:S2772963X23000492?httpAccept=text/plainIdentifier: 2
Identifier: 3
