Year: 2021
Type: Article
Title: The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu
Author: Figurek, Andreja
Author: Rroji, Merita
Author: Spasovski, Goce
Abstract: Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). This review summarizes the current knowledge of FGF23 mechanisms of action in the myocardium in the physiological and pathophysiological state of CKD, as well as its cross-talk to other important signaling pathways in cardiomyocytes. In this regard, current therapeutic possibilities and future perspectives are also discussed.
Publisher: MDPI AG
Relation: Cells
Identifier: oai:repository.ukim.mk:20.500.12188/26784
Identifier: http://hdl.handle.net/20.500.12188/26784Identifier: 10.3390/cells10051266
Identifier: https://www.mdpi.com/2073-4409/10/5/1266/pdfIdentifier: 10
Identifier: 5
