Year: 2022
Type: Proceeding article
Title: Plasmacytoma of the testis as initial presentation of multiple myeloma: case report
Author: Tanevska Zrmanovska, Aneta
Author: Krsteska, Blagica
Author: Petrushevska, Gordana
Abstract: Background & objectives: Extramedullary plasmacytoma represents 5% of plasma cell neoplasms. Plasmacytoma of the testis is extremely rare and may occur as isolated tumour or in concomitance with multiple myeloma. We report a case of testicular plasmacytoma in 77-year-old male patient. Methods: The physical examination and ultrasonography revealed enlarged left testicle. Based on a clinical diagnosis, an inguinal orchidectomy was performed. On gross examination the testicle measured 7x4x4cm and was entirely occupied by a solid white fleshy tumour. Formalin fixed, paraffin embedded tissue samples were stained with HE and immunohistochemically with CD138, MUM 1, CD79, CD3, CD20, CD117, PLAP and Ki 67. Results: Microscopic examination revealed a malignant neoplasm composed of atypical plasma cells with pale eosinophilic cytoplasm and polymorphic and polychromatic nuclei which diffusely obliterated underlying testicular parenchyma and infiltrating the epididymis and surrounding peritesticular fibrous tissue. Immunohistochemically the cells were positive for CD138, MUM1 and CD79 and negative for CD3, CD20, CD117 and PLAP with Ki67 80%. After period of two and half months the diagnose of multiple myeloma was established with bone marrow aspiration showed 60% plasma cells, flow cytometry with CD38 and CD138 plasma cells and serum protein immunoelectrophoresis IgA idiotype. Patient died after two-week therapy with corticosteroids, four months after initiate diagnose of plasmacytoma of testis. Conclusion: Testicular plasmacytoma is extremely rare presentation of extramedullary plasmacytoma. Taking into account the additional data obtained about the patient we concluded that in our case it was the first manifestation of systemic disease referred as multiple myeloma.
Publisher:
Relation: 34th European Congress of pathology
Identifier: oai:repository.ukim.mk:20.500.12188/26605
Identifier: http://hdl.handle.net/20.500.12188/26605
