Year: 2011
Type: Article
Title: Acute graft versus host disease in hematopoietic stem cell alotransplant recipients
Author: Krstevska, Svetlana
Author: Genadieva Stavrikj, Sonja
Author: Pivkova, Aleksandra
Author: Stojanoski, Zlate
Author: Georgievski, Borce
Author: Balkanov, Trajan
Abstract: The transplantation of hematopoietic stem cells (HSCT) is a therapeutic intervention where the hematopoietic stem cells and the cells originating from them are being removed and replaced by the normal stem cells of donor or the patient him/her-self. HSCT today represent standardized biological manipulation for treating malignant, genetic and autoimmune diseases. The application of allogeneic hematopoietic stem cell transplantation (HSCT) is limited by life-threatening complications such as severe or acute graft-versus-host disease (GVHD). Despite intensive prophylaxis with immunosuppressive agents, the incidence of GVHD occurs in 9-50% of patients undergoing transplant with an identical HLA sibling matched donor and 75% of patients undergoing unrelated HLA donors.
Publisher: ScopeMed
Relation: Medicinski arhiv
Identifier: oai:repository.ukim.mk:20.500.12188/26531
Identifier: http://hdl.handle.net/20.500.12188/26531Identifier: http://www.scopemed.org/fulltextpdf.php?mno=12160Identifier: 65
Identifier: 5
