Year: 2022
Type: Article
Title: Hematological Findings and Alteration of Oxidative Stress Markers in Hospitalized Patients with SARS-COV-2
Author: Gjorgjievska, Kalina
Author: Petrushevska, Marija
Author: Zendelovska, Dragica
Author: Atanasovska, Emilija
Author: Spasovska, Katerina
Author: Stevanovikj, Milena
Author: Grozdanovski, Krsto
Abstract: Background/aim: Hematological parameters are the starting point in COVID-19 severity classification. The aim of this study was to analyze oxidative stress in hospitalized COVID-19 patients and to determine its association with D-dimer, neutrophil to lymphocyte ratio (NLR), and platelets to lymphocyte ratio (PLR) as markers for disease progression. Materials and methods: 52 patients with moderate and severe forms of COVID-19 were enrolled. A hematological and coagulation profile was performed for each patient. PAT (total antioxidant power, iron-reducing) and d-ROMs (plasma peroxides) were determined in serum at admission and 7 days after hospitalization. Results: The severe group presented parameters that indicated a poor prognosis. Patients that recovered had a significant reduction in d-ROM (t-test, p<0.01) and improvement in oxidative stress index (t-test, p<0.05). Patients that died had significantly decreased PAT (p<0.01) resulting in an increase in oxidative stress. Except for d-ROM vs PLR in both groups and d-ROM vs D-dimer in the severe group, a good correlation between oxidative stress parameters and D-dimer, PLR, and NLR was demonstrated (p<0.01). Conclusion: Our results show that oxidative stress markers can be used as a tool for disease progression in COVID-19. This analysis is easily accessible and affordable in addition to conventional hematological parameters performed for severity classification.
Publisher: Macedonian Academy of Sciences and Arts/Sciendo
Relation: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
Identifier: oai:repository.ukim.mk:20.500.12188/26094
Identifier: http://hdl.handle.net/20.500.12188/26094Identifier: 10.2478/prilozi-2022-0029
Identifier: https://www.sciendo.com/pdf/10.2478/prilozi-2022-0029Identifier: 43
Identifier: 2
