Subject: myocardial infarction
Subject: cardiac biomarkers
Subject: cardiac troponin
Subject: natriuretic peptide
Subject: prognosis
Subject: major adverse cardiac events (MACE)
Subject: cardiac death
Year: 2022
Type: Article
Title: Incremental Value of Cardiac Biomarkers in Mid-term Prognosis of Patients with Acute Coronary Syndrome
Author: Serafimov, A
Author: Donevski, D
Author: Karakolevska Ilova, M
Author: Joveva, E
Author: Todosieva Serafimova, K
Author: Kedev, S
Author: Vavlukis, Marija
Abstract: Background: Given the number of prognostic studies, both short- and long-termed, in patients with myocardial infarction (MI), the data on predicting major adverse cardiac events (MACE) following discharge still remains limited. Aim: to identify early predictors of MACE in MI patients, that underwent Primary Percutaneous Coronary Intervention (pPCI), with special emphasis on multiple cardiac biomarkers. Materials and methods: we analysed clinical, LV functional, angiographic variables, as well cardiac troponin, a marker of myocardial necrosis, natriuretic peptide (NT-proBNP), a marker of myocardial stress, and white blood cells (WBC), as a marker of inflammation. The study population were 150 consecutive patients treated for acute myocardial infarction. Results: The average follow-up period was 31 months. In total, 26 patients suffered from at least one MACE. Multivariate logistic regression analysis identified several independent predictors: NT-proBNP (p=0,07), number of diseased vessels (p=0,027), and need for loop diuretic therapy (p=0,050). ROC curve demonstrated excellent discriminatory function for MACE of NT-proBNP and WBC (area under the curve .640, and .658, p=0.025 and 0.011 respectively). Conclusion: The combination of biomarkers for myocardial stress and inflammation improves the prediction of major adverse cardiac events in MI survivors.
Publisher: Scientific Foundation SPIROSKI
Relation: OPEN ACCESS MACEDONIAN JOURNAL OF MEDICAL SCIENCES
Identifier: oai:repository.ukim.mk:20.500.12188/25322
Identifier: Serafimov A, Donevski D, Karakolevska Ilova M, Joveva E, Todosieva Serafimova K, Kedev S, Vavlukis M. Incremental Value of Cardiac Biomarkers in Mid-term Prognosis of Patients with Acute Coronary Syndrome. Open Access Maced J Med Sci [Internet]. 2022 Feb. 14 [cited 2023 Jan. 2];10(B):294-302. Available from: https://oamjms.eu/index.php/mjms/article/view/7978Identifier: http://hdl.handle.net/20.500.12188/25322
