Subject: diffuse axonal injury
Subject: β-amyloid precursor protein
Subject: immunohistochemistry
Subject: forensic medicine.
Year: 2015
Type: Article
Title: The Role of the Beta-Amyloid Precursor Protein in the Diagnosis of Diffuse Axonal Injury
Author: Davcheva, N
Author: Dimitrova, M
Author: Kadiysky, D
Author: Grozeva, M
Author: Basheska, N
Abstract: Diffuse axonal injury (DAI) is a distinct clinical-pathological entity in the closed head injuries, where very often, the macroscopic lesion of the brain tissue cannot be found. Hence, in those cases the microscopic examination is of a huge importance. Using the conventional staining techniques the axonal injuries can be perceived only if there has been a survival of up to 24 hours (hematoxylin and eosin staining), or 12 to 18 hours (silver impregnation methods). With the introduction of immunohistochemistry using antibodies against β-Amyloid Precursor Protein (β-APP), this period has been shortened to 3 hours, even less. In the present paper, a review on the role of β-APP immunohistochemistry in the diagnosis of DAI is presented. This review shows that β-APP immunohistochemistry can be a very powerful tool in diagnosing the axonal injuries, what is of a special significance for the forensic medicine practice.
Publisher: Bulgarian Academy of Sciences, Prof. Marin Drinov Publishing House
Relation: Acta morphologica et anthropologica
Identifier: oai:repository.ukim.mk:20.500.12188/24764
Identifier: 1311-8773
Identifier: http://hdl.handle.net/20.500.12188/24764Identifier: 2535-0811
