Year: 2019
Type: Article
Title: Brucellosis in pregnancy: results of multicenter ID-IRI study
Author: Inan, Asuman
Author: Erdem, Hakan
Author: Elaldi, Nazif
Author: Gulsun, Serda
Author: Karahocagil, Mustafa K
Author: Pekok, Abdullah U
Author: Ulug, Mehmet
Author: Tekin, Recep
Author: Bosilkovski, Mile
Author: Kaya, Safak
Author: Haykir-Solay, Asli
Author: Demirdal, Tuna
Author: Kaya, Selcuk
Author: Sunnetcioglu, Mahmut
Author: Sener, Alper
Author: Tosun, Selma
Author: Aydin, Emsal
Author: Ural, Serap
Author: Yamazhan, Tansu
Author: Muhcu, Murat
Author: Ayaslioglu, Ergin
Author: Bilgic-Atli, Seval
Author: Erbay, Ayse
Author: Ergen, Pinar
Author: Kadanali, Ayten
Author: Sahin, Suzan
Author: Sahin-Horasan, Elif
Author: Avci, Ali
Author: Cag, Yakup
Author: Beeching, Nicholas J
Abstract: Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p = 0.019), nausea and/or vomiting (p < 0.001), vaginal bleeding (p < 0.001), anemia (blood hemoglobin < 11 g/dL; p < 0.001), high level of serum aspartate aminotransferase (> 41 IU/L; p = 0.025), oligohydramnios on ultrasonography (p = 0.0002), history of taking medication other than Brucella treatment during pregnancy (p = 0.027), and Brucella bacteremia (p = 0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.
Publisher: Springer Science and Business Media LLC
Relation: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Identifier: oai:repository.ukim.mk:20.500.12188/24598
Identifier: http://hdl.handle.net/20.500.12188/24598Identifier: 10.1007/s10096-019-03540-z
Identifier: http://link.springer.com/content/pdf/10.1007/s10096-019-03540-z.pdfIdentifier: http://link.springer.com/article/10.1007/s10096-019-03540-z/fulltext.htmlIdentifier: http://link.springer.com/content/pdf/10.1007/s10096-019-03540-z.pdfIdentifier: 38
Identifier: 7
