Subject: Chronic kidney failure
Subject: electron microscopy
Subject: glomerulonephritis
Subject: immunosuppression therapy
Subject: nephrotic syndrome
Year: 2022
Type: Article
Title: Immunotactoid glomerulopathy: A rare glomerular disease case study
Author: Dzekova Vidimliski, Pavlina
Author: Karanfilovski, Vlatko
Author: Ristovska, Vesna
Author: Gjorgjievski, Nikola
Author: Nikolov, Igor
Author: Petrushevska, Gordana
Abstract: Immunotactoid glomerulopathy (ITG) is a rare glomerular disease with variable responsiveness to the immunosuppressive therapy and with uncertain prognosis. ITG was diagnosed in two patients with type 2 diabetes mellitus with nephrotic syndrome and chronic kidney disease. The absence of diabetic retinopathy in the first case and the recent onset of diabetes in the second case accompanied with sudden increase in the 24‑hour proteinuria and rapid decline in kidney function, prompted us to perform kidney biopsy. The electron microscopy set the diagnosis of ITG in both cases. There is no consensus for the treatment of ITG. The first patient was treated with combination of steroids and mycophenolate mofetil with reduction of the 24‑hour proteinuria, but with persistence of the chronic kidney disease. The second patient received high doses of steroids with continuous deterioration of kidney function with the need of hemodialysis treatment.
Publisher: Medknow
Relation: Indian Journal of Nephrology
Identifier: oai:repository.ukim.mk:20.500.12188/23751
Identifier: http://hdl.handle.net/20.500.12188/23751Identifier: 10.4103/ijn.ijn_107_22
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