Subject: Image-guided cancer surgery
Subject: tumor detection
Subject: sentinel lymph node mapping
Subject: multiscale spectral imaging
Subject: stacked photodiode image sensor
Subject: pixelated optical filter
Year: 2022
Type: Article
Title: Decoupling channel count from field of view and spatial resolution in single-sensor imaging systems for fluorescence image-guided surgery
Author: Blair, Steven
Author: Garcia, Missael
Author: Zhu, Zhongmin
Author: Liang, Zuodong
Author: Lew, Benjamin
Author: George, Mebin
Author: Kondov, Borislav
Author: Stojanoski, Sinisha
Author: Bogdanovska Todorovska, Magdalena
Author: Miladinova, Daniela
Author: Kondov, Goran
Author: Gruev, Viktor
Abstract: Near-infrared fluorescence image-guided surgery is often thought of as a spectral imaging problem where the channel count is the critical parameter, but it should also be thought of as a multiscale imaging problem where the field of view and spatial resolution are similarly important. Aim Conventional imaging systems based on division-of-focal-plane architectures suffer from a strict relationship between the channel count on one hand and the field of view and spatial resolution on the other, but bioinspired imaging systems that combine stacked photodiode image sensors and long-pass/short-pass filter arrays offer a weaker tradeoff. Approach In this paper, we explore how the relevant changes to the image sensor and associated image processing routines affect image fidelity during image-guided surgeries for tumor removal in an animal model of breast cancer and nodal mapping in women with breast cancer. Results We demonstrate that a transition from a conventional imaging system to a bioinspired one, along with optimization of the image processing routines, yields improvements in multiple measures of spectral and textural rendition relevant to surgical decision-making. Conclusions These results call for a critical examination of the devices and algorithms that underpin image-guided surgery to ensure that surgeons receive high-quality guidance and patients receive high-quality outcomes as these technologies enter clinical practice.
Publisher: SPIE-Intl Soc Optical Eng
Relation: Journal of Biomedical Optics
Identifier: oai:repository.ukim.mk:20.500.12188/23546
Identifier: http://hdl.handle.net/20.500.12188/23546Identifier: 10.1117/1.jbo.27.9.096006
Identifier: 27
Identifier: 09
