Subject: Chronic myeloic leukemia
Subject: Imatinib
Subject: Philadelphia chromosome
Subject: clone evlotion
Year: 2013
Type: Article
Title: CHROMOSOMAL ABNORMALITIES IN PHILADELPHIA CHROMOSOME- NEGATIVE CELLS IN PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH FIRST GENERATION TYROSINE KINASE INHIBITOR- SINGLE CENTER EXPERIENCE
Author: Trajkova, Sanja
Author: Chevrevska, Lidija
Author: Pavkovic, Marica
Author: Panovska Stavridis, Irina
Author: Dukovski, Dushko
Author: Popova-Simjanovska Marija
Author: Chadievski, Lazar
Author: Stojanovikj, Aleksandar
Abstract: Chronic myelogenous leukemia (CML) is characterized by the presence of a Bcr-Abl fusion protein with deregulated tyrosine kinase activity that is required for maintaining the malignant phenotype. Imatinib as a selective inhibitor of Bcr-Abl induces complete cytogenetic remission in the majority of patients with CML in chronic phase. Targeted therapy of CML with imatinib favors the manifestation of Ph-(negative) clone disorders in some patients. Facts indicate that patients on imatinib should be followed with conventional cytogenetics, even after induction of complete remission. We report a case of a patient with CML, in chronic phase treated with imatinib which induces the most common abnormality trisomy 8.
Publisher: Radiance Research Academy
Relation: International Journal of Current Research and Review
Identifier: oai:repository.ukim.mk:20.500.12188/23494
Identifier: http://hdl.handle.net/20.500.12188/23494Identifier: 05
Identifier: 10
