Subject: IVF, preimplantation genetic testing for aneuploidy, chromosomal aberrations, oocyte donor, paternal age, meta-analysis
Year: 2021
Type: Article
Title: Is there an association between paternal age and aneuploidy? Evidence from young donor oocyte-derived embryos: a systematic review and individual patient data meta-analysis
Author: Dviri, Michal
Author: Madjunkova, Svetlana
Author: Koziarz, Alex
Author: Madjunkov, Mitko
Author: Mashiach, Jordana
Author: Nekolaichuk, Erica
Author: Trivodaliev, Kire
Author: Al-Asmar, Nasser
Author: Moskovtsev, Sergey Ivanovovich
Author: Librach, Clifford
Abstract: Delayed parenthood, by both women and men, has become more common in developed countries. The adverse effect of advanced maternal age on embryo aneuploidy and reproductive outcomes is well known. However, whether there is an association between paternal age (PA) and embryonic chromosomal aberrations remains controversial. Oocyte donation (OD) is often utilized to minimize maternal age effects on oocyte and embryo aneuploidy, thus providing an optimal model to assess the effect of PA. Several studies have revealed a higher than expected rate of aneuploidy in embryos derived from young oocyte donors, which warrants examination as to whether this may be attributed to advanced PA (APA).
Publisher: Oxford University Press (OUP)
Relation: Human Reproduction Update
Identifier: oai:repository.ukim.mk:20.500.12188/19591
Identifier: http://hdl.handle.net/20.500.12188/19591Identifier: 10.1093/humupd/dmaa052
Identifier: http://academic.oup.com/humupd/article-pdf/27/3/486/37248777/dmaa052.pdfIdentifier: http://academic.oup.com/humupd/article-pdf/27/3/486/37248777/dmaa052.pdfIdentifier: 27
Identifier: 3
Identifier: 486
Identifier: 500
