Subject: allogeneic transplantation
Subject: acute and chronic GvHD
Subject: conditioning regimen
Subject: donor-recipient match
Subject: immune system
Year: 2021
Type: Article
Title: Graft-versus-host disease in patients treated with allogenic hematopoetic cell transplantation: experience from North Macedonia
Author: Mickovski, Ivana
Author: Buklioska Ilievska, Daniela
Author: Georgievski, Borche
Author: Hasan, Taner
Author: Nedeska Minova, Natasha
Author: Neshovska, Radmila
Author: Doneva, Daniela
Abstract: Introduction: Graft-versus-host disease (GvHD) is the major complication arising after allogeneic hematopoietic cell transplantation (allo-HCT). It can be presented as acute and/or chronic GvHD. The purpose of this study was describe the incidence of acute and chronic GvHD in patients treated with allo-HCT. Materials and methods: This study was designed as a retrospective study, which included 65 patients treated with allogeneic transplantation from human leukocyte antigen identical donor at University Clinic of Hematology in Skopje, North Macedonia. Results: Acute GvHD (aGvHD) was observed in 28 patients, with the most common localization on the skin (75%). Post-transplant phase had significant effect on the frequency of skin aGvHD (p =0.038). Also statistically significant difference was confirmed between patients with and without acute skin GvHD in terms of conditioning regimen (p =0.034). Chronic GvHD (cGvHD) was diagnosed in 10 patients, mostly progressing from the previous acute GvHD (9.23%). Post-transplant phase had also significant effect on the frequency of skin cGvHD (p =0.018). Patients with higher European Society for Blood and Marrow Transplantation risk score had significantly more frequent skin cGvHD than the others. Conclusions: Acute and chronic GvHD were one of the main causes of morbidity and mortality of patients after aloo-HCT. GvHD remains a major risk for patients with allo-HCT regardless of diagnosis and type of transplantation.
Publisher: VM Media SP. zo.o VM Group SK
Relation: Acta Haematologica Polonica
Identifier: oai:repository.ukim.mk:20.500.12188/18465
Identifier: Mickovski I, Bukliovska Ilievska D, Georgievski B, Hasan T, Nedeska Minova N, Neshovska R, Doneva D. Graft-versus-host disease in patients treated with allogenic hematopoetic cell transplantation: experience from North Macedonia. Acta Haematologica Polonica 2021 Number 5, Volume 52, pages 509–515
Identifier: http://hdl.handle.net/20.500.12188/18465Identifier: 10.5603/ahp.2021.0090
Identifier: https://journals.viamedica.pl/acta_haematologica_polonica/article/viewFile/85907/64631Identifier: 52
Identifier: 5
