Subject: CNS lymphoma
Subject: Non-Hodgkin lymphoma
Subject: brain tumors
Year: 2018
Type: Proceeding article
Title: Primary CNS lymphomas – 20-year-period evaluation study
Author: Ilievski, B
Author: Zdravkovski, P
Author: Cvetkovski, P
Author: Filipche, V
Author: CHaparoski, A
Author: Lazareska, M
Author: Petrushevska, G
Abstract: Background & Objective: Primary CNS lymphoma is an extra-nodal, non-Hodgkin lymphoma (NHL) confined to the cranio-spinal axis (brain, eye, meninges, spinal cord) without evidence of systemic involvement. Most prevalent form is Diffuse Large B-cell lymphoma (DLBCL). The aim of this study is to evaluate statistical features of this malignancy in Republic of Macedonia. Method: This is a 20-year-period retrospective evaluation study (1998-2018) of 45 primary CNS limphoma cases operated in the University Neurosurgery Clinic, diagnosed at the Institute of Pathology, Medical Faculty-UKIM, Skopje, Macedonia using histological and immunohistochemical analyses (exclusion, diagnostic NHL and subtype-specific immunohistochemistry algorithms). Statistica for Windows 7 was used. Results: From total 4929 cases of benign and malignant brain tumours, primary CNS lymphomas comprise 45 cases (0,91%); 24(53,3%) males (55,0±14,7 years), 21(46,7%) females (57,9±14,8 years), age 8 to 74 years (56,4±14,6 years); most common localization: cerebrum – 13(28,9%) cases. Age group distribution: most cases -15(33,3%) in 60-69 years group, only 1(2,2%) in 0-19 years group. DLBCL was diagnosed in 30(66,7%) cases, the rest subtypes in 15(33,3%) cases. There was no significant difference between the age of males and females diagnosed with primary CNS lymphoma (Mann-Whitney U test: Z=1,104; p=0,2695). There was no significant statistical difference between age groups and lymphoma subtypes (Kruskal-Wallis ANOVA: H=5,099; p=0,5311). Conclusion: We found that DLBCL was diagnosed in 2/3 of the cases and no significant difference of lymphoma subtype between males and females.
Publisher: Springer
Relation: Virchows Archiv: European Journal of Pathology
Identifier: oai:repository.ukim.mk:20.500.12188/17837
Identifier: 0945-6317
Identifier: http://hdl.handle.net/20.500.12188/17837Identifier: 473
Identifier: 1
