Year: 2005
Type: Article
Title: Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia
Author: Laurenti, Luca
Author: Petlickovski, Aleksandar
Author: Rumi, Carlo
Author: Gobessi, Stefania
Author: Piccioni, Paola
Author: Tarnani, Michela
Author: Puggioni, Pierluigi
Author: Marietti, Sara
Author: Sica, Simona
Author: Leone, Giuseppe
Author: Efremov, Dimitar G
Abstract: The protein tyrosine kinase ZAP-70 has recently emerged as a major prognostic indicator in chronic lymphocytic leukemia (CLL). ZAP-70 is structurally and functionally homologous to Syk, a key mediator of B-cell receptor signaling. We therefore evaluated ZAP-70 expression in CLL B cells using Syk as an intracellular standard.
Publisher:
Relation: Haematologica
Identifier: oai:repository.ukim.mk:20.500.12188/1770
Identifier: http://hdl.handle.net/20.500.12188/1770Identifier: 90
Identifier: 11
