Subject: Antipsychotic agents
Subject: lithium
Subject: neuroleptic malignant syndrome
Subject: renal insufficiency
Year: 2021
Type: Article
Title: Neurotoxicity and Renal Impairment in a Patient with Acute Poisoning with Antipsychotic Drugs-Literature Review
Author: Simonovska, Natasha
Author: Babulovska, Aleksandra
Author: Pereska, Zanina
Author: Kostadinovski, Kristin
Abstract: Neuroleptic malignant syndrome is a rare, severe and potentially fatal condition characterized by hyperthermia, muscle rigidity, changes in mental status (delirium, altered consciousness). There are many risk factors responsible for development of this syndrome such as the use of high-dose, high-potency and long-acting antipsychotic drugs, rapid increase in the dosage, using multiple antipsychotic drugs or other medications like antidepressants and mood stabilizers, especially lithium. A correlation between chronic kidney diesease and sudden lithium intoxication has been postulated, but the relationship between both remains unclear. We present here a case with neurotoxicity, rhabdomyolysis, renal impairment and hyperparathyroidism caused by acute poisoning with lithium, haloperidol, diazepam. The purpose of this case report is to increase awareness and vigilance of the fact that concurrent use of multiple antipsychotic and other drugs may cause multiple organ failures.
Publisher:
Relation: Türkiye Klinikleri Journal of Case Reports
Identifier: oai:repository.ukim.mk:20.500.12188/15973
Identifier: http://hdl.handle.net/20.500.12188/15973Identifier: 10.5336/caserep.2021-83290
