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Year: 2021

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Type: Article

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Title: Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study

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Author: Petrushevska, Marija
Author: Zendelovska, Dragica
Author: Atanasovska, Emilija
Author: Eftimov, Aleksandar
Author: Spasovska, Katerina

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Abstract: Introduction: COVID-19 can be worsened by hyper-production of cytokines accompanied by increased level of oxidative stress. The aim of this study was to investigate the correlation between a set of cytokines and the markers of the oxidative stress. Methods: The levels of cytokines IL-2, IL-4, IL-6, IL8, IL-10, VEGF, IFN-γ, TNF-α, IL-1α, MCP-1 and EGF were determined by using High Sensitivity Evidence Investigator™ Biochip Array technology. The oxidative stress parameters (d-ROM, PAT, OS index) were measured in serum on FRAS5 analytical photometric system. Results: IL-6, IL-8, IL-10, VEGF, MCP-1 and EGF were significantly higher (p<0.05) in the patients with severe COVID-19 with increased levels of IL-2, IFN-y, TNF-α and IL-1α. The d-ROM, OS index, and PAT were significantly higher (p<0.05) in severe COVID-19 patients. IL-6 demonstrated the strongest correlation with all of the markers of the oxidative stress, d-ROM (r=0.9725, p=0.0001), PAT (r=0.5000, p=0.0001) and OS index (r=0.9593, p=0.012). Similar behavior was evidenced between IFN-y and d-ROM (r=0.4006, p=0.0001), PAT (r=0.6030, p=0.0001) and OS index (r=0.4298, p=0.012). Conclusion: The oxidative stress markers show good correlation with the tested cytokines which can be measured at the beginning of the disease in a primary care setting to predict the course of COVID-19.

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Publisher: F1000 Research Ltd

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Relation: F1000Research

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Identifier: oai:repository.ukim.mk:20.500.12188/15494
Identifier: http://hdl.handle.net/20.500.12188/15494
Identifier: 10.12688/f1000research.55166.2
Identifier: https://f1000research.com/articles/10-719/v2/xml
Identifier: https://f1000research.com/articles/10-719/v2/pdf
Identifier: https://f1000research.com/articles/10-719/v2/iparadigms
Identifier: 10

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