Year: 2015
Type: Article
Title: Severe Endothelial Damage in Chronic Kidney Disease Patients Prior to Haemodialysis Vascular Access Surgery
Author: Vladimir Pushevski
Author: Petar Dejanov
Author: Vesna Gerasimovska
Author: Gordana Petrushevska
Author: Angel Oncevski
Author: Aleksandar Sikole
Author: Zivko Popov
Author: Ninoslav Ivanovski
Abstract: Hemodialysis as an efficient therapy for advanced CKD is the most used treatment modality all over the world. Even though primary AVF is widely accepted as a best permanent vascular access in hemodialysis patients, up to 60% of all fistulas fail to mature. The pathogenesis of early fistula failure is not very well understood. Many general and local factors are involved: patient's age, sex, primary renal disease, small vessel's diameter, presence of accessory veins, prior venipunctures, surgical skill, genetics, etc. Histological investigations have confirmed the neointimal venous hyperplasia as a major pathological finding in stenotic lesions of AVF failure, due to local inflammation, oxidative stress and migration and proliferation of myofibroblasts, fibroblasts and endothelial cells.
Publisher: Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH
Relation: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
Identifier: oai:repository.ukim.mk:20.500.12188/15291
Identifier: 1857-9345
Identifier: http://hdl.handle.net/20.500.12188/15291Identifier: 10.1515/prilozi-2015-0077
Identifier: http://content.sciendo.com/view/journals/prilozi/36/3/article-p43.xmlIdentifier: https://www.sciendo.com/article/10.1515/prilozi-2015-0077Identifier: 36
Identifier: 3
Identifier: 43
Identifier: 49
