Year: 2012
Title: Secondary metabolite production in Hypericum perforatum L. cell suspensions upon elicitation with fungal mycelia from Aspergillus flavus
Author: Gadzovska-Simic, Sonja
Author: Tusevski, O.
Author: Antevski, S.
Author: Atanasova-Pancevska, Natalija
Author: Petreska, Jasmina
Author: Stefova, Marina
Author: Kungulovski, D.
Author: Spasenoski, M.
Abstract: We investigated the production of phenylpropanoids (phenolic compounds, flavanols, flavonols and anthocyanins) and naphtodianthrones (hypericins) in elicited Hypericum perforatum L. cell suspensions. To determine whether secondary metabolite production could be enhanced, Hypericum cell suspensions were exposed to mycelia extract from the fungus Aspergillus flavus. Elicited Hypericum cell suspension cultures displayed reduced growth and viability and a modification of secondary metabolites production. Anthocyanins were only stimulated in fungal-elicited cell suspensions. Secondary metabolite production in elicited Hypericum cells revealed an antagonism between the flavonoid/naphtodianthrone and anthocyanin pathways. The data suggest a modification of the channeling of the phenylpropanoid compounds. Together, these results represent useful data for monitoring the channeling in different secondary metabolite pathways during the scaled-up production of naphtodianthrones for medicinal uses.
Publisher: National Library of Serbia
Relation: Archives of Biological Sciences
Identifier: oai:repository.ukim.mk:20.500.12188/14991
Identifier: http://hdl.handle.net/20.500.12188/14991Identifier: 10.2298/abs1201113g
Identifier: 64
Identifier: 1
