Year: 2013
Type: Article
Title: Evolution of cardiorespiratory interactions with age
Author: Iatsenko, D
Author: Bernjak, A
Author: Stankovski, Tomislav
Author: Shiogai, Y
Author: Owen-Lynch, P J
Author: Clarkson, P B M
Author: McClintock, P V E
Author: Stefanovska, A
Abstract: We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure. By treating the heart and respiration as coupled oscillators, we then apply a method based on Bayesian inference to find the underlying coupling parameters and their time dependence, deriving from them measures such as synchronization, coupling directionality and the relative contributions of different mechanisms. We report a detailed analysis of the reconstructed cardiorespiratory coupling function, its time evolution and age dependence. We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.
Publisher: The Royal Society
Relation: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Identifier: oai:repository.ukim.mk:20.500.12188/1474
Identifier: 1364-503X
Identifier: http://hdl.handle.net/20.500.12188/1474Identifier: 10.1098/rsta.2011.0622
Identifier: https://syndication.highwire.org/content/doi/10.1098/rsta.2011.0622Identifier: 371
Identifier: 1997
