Subject: asthma
Subject: vitamin D
Subject: IL-33
Subject: FEV1
Subject: Th2-type cytokines
Year: 2017
Type: Article
Title: Relationship between Vitamin D, Inflammation and Lung Function In Patients with Severe Uncontrolled Asthma
Author: Jovanovska-Janeva, Elena
Author: Dokic, Dejan
Author: Jovkovska-Kaeva, Biserka
Author: Breskovska, Gorica
Author: Goseva, Zlatica
Author: Minov, Jordan
Author: Trajkov, Dejan
Author: Genadieva-Dimitrova, Magdalena
Author: Zafirovska-Ivanovska, Beti
Abstract: BACKGROUND:Recently epidemiological studies showed that low vitamin D is linked toairway hyperresponsiveness, decreasedlung function, poor asthma control, and steroid–resistant asthma.AIM:We investigatedtherelationshipbetween Vitamin D, inflammation with circulating IL-33 and lung function in 30 patients with severe uncontrolled asthma. MATERIALS AND METHODS:The study included 30 patients with severe uncontrolled asthma. In each of them were measured serum levels of IL-33 and Vitamin D by the ELISA method. The pulmonary function is measuredby basic spirometry parameters, FEV1. The results were statistically elaboratedaccording to the Pearson’s Correlation Tests. RESULTS:The results showed statistically insignificant correlation between Vitamin D and IL-33, and Vitamin D with FEV1 (Vit.D/IL-33; r=0.11323, p=0.551); (Vit.D/FEV1; r=-0.1005; p=0.597) Correlation between IL-33 and FEV1 is negative but statistically significant (IL-33/FEV1; r=-0.5248; p=0.003). CONCLUSION:Because there arelittle studies about the link between vitamin D and asthma, further research toclarify the mechanism how vitamin D control the activity of CD4+ T cells and the related Th2-type cytokines in the parthenogenesis of asthma.
Publisher: Scientific Foundation SPIROSKI
Relation: Open Access Macedonian Journal of Medical Sciences
Identifier: oai:repository.ukim.mk:20.500.12188/14614
Identifier: 1857-9655
Identifier: http://hdl.handle.net/20.500.12188/14614Identifier: 10.3889/oamjms.2017.190
Identifier: https://spiroski.migration.publicknowledgeproject.org/index.php/mjms/article/download/oamjms.2017.190/1699Identifier: https://spiroski.migration.publicknowledgeproject.org/index.php/mjms/article/download/oamjms.2017.190/1656Identifier: 5
Identifier: 7
