Subject: Hydroxyurea therapy
Subject: Cutaneous side effects
Subject: Leg ulcer
Subject: Basal cell carcinoma
Year: 2018
Type: Article
Title: Hydroxyurea Associated Cutaneous Lesions: A Case Report
Author: Simeonovski Viktor
Author: Hristina Breshkovska
Author: Silvija Duma
Author: Dohcheva Karajovanov, Ivana
Author: Katerina Damevska
Author: Suzana Nikolovska
Abstract: Hydroxyurea (HU) is an antimetabolite agent that interferes with the S-phase of cellular replication and inhibits DNA synthesis, with little or no effect on RNA or protein synthesis. It is used in the treatment of many myeloproliferative disorders (MD) and is particularly a first line treatment drug for intermediate to high-risk essential thrombocythemia. Although safe and very well tolerated by the patients suffering from MD, there have been numerous reports of a broad palette of cutaneous side effects associated with prolonged intake of the medication. These may include classical symptoms such as xerosis, diffuse hyperpigmentation, brown-nail discolouration, stomatitis and scaling of the face, hands, and feet or more serious side effects such as actinic keratosis lesions, leg ulcers and multiple skin carcinomas.
Publisher: Scientific Foundation SPIROSKI
Relation: Open Access Macedonian Journal of Medical Sciences
Identifier: oai:repository.ukim.mk:20.500.12188/12606
Identifier: http://hdl.handle.net/20.500.12188/12606
