Year: 1993
Type: Article
Title: Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation
Author: Starzl, T E
Author: Demetris, A J
Author: Trucco, M
Author: Zeevi, A
Author: Ramos, H
Author: Terasaki, P
Author: Rudert, W A
Author: Kocova, M
Author: Ricordi, C
Author: Ildstad, S
Abstract: Chimerism was demonstrated with immunocytochemical and/or polymerase chain reaction techniques in kidney allografts and in the native skin, lymph nodes, or blood of 5 of 5 patients who received continuously functioning renal transplants from 1 or 2 haplotype HLA mismatched consanguineous donors (4 parents, 1 aunt) 27-29 years ago. In the 4 cases where the kidney donor still was alive to provide stimulator lymphocytes for testing, these provoked no (n = 2) or modest (n = 2) MLR in contrast to vigorous MLR to third party lymphocytes. In all 4 cases, the donor cells failed to generate in vitro cytotoxic effector cells (cell-mediated lymphocytotoxicity). These findings are in accord with the hypothesis that cell migration, repopulation, and chimerism are seminal events that define graft acceptance and ultimately can lead to acquired donor-specific nonresponsiveness (tolerance).
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Relation: Transplantation
Identifier: oai:repository.ukim.mk:20.500.12188/11562
Identifier: 0041-1337
Identifier: http://hdl.handle.net/20.500.12188/11562Identifier: 10.1097/00007890-199306000-00012
Identifier: 55
Identifier: 6
