Year: 1986
Type: Article
Title: Secondary acute myeloblastic leukemia with a Ph translocation in a treated Wegener's granulomatosis
Author: Ohyashiki, K
Author: Kocova, M
Author: Ryan, D H
Author: Rowe, J M
Author: Sandberg, A A
Abstract: Ph-positive acute myeloblastic leukemia (AML) developing in a treated case of Wegener's granulomatosis is reported. The patient was a 70-year-old white male who received cyclophosphamide (150 mg/day) starting in July 1978; in May 1984 the patient was diagnosed as having AML, following a diagnosis of myelodysplastic syndrome lasting 3 months. Cytogenetic study of bone marrow cells at the diagnosis of the myelodysplastic syndrome revealed a standard Ph translocation in addition to numerical chromosome changes [i.e., 45,XY, -5, -7, -8, +19, +mar/45,XY, -5, -7, -8, +19, +mar,t(9;22)(q34;q11]). The events in this case suggest a strong possibility of the Ph-positive AML being a secondary disease related to prior cyclophosphamide therapy.
Publisher: ELSEVIER SCIENCE INC
Relation: Cancer genetics and cytogenetics
Identifier: oai:repository.ukim.mk:20.500.12188/11553
Identifier: 0165-4608
Identifier: http://hdl.handle.net/20.500.12188/11553Identifier: 10.1016/0165-4608(86)90062-2
Identifier: 19
Identifier: 3-4
