Year: 1985
Type: Article
Title: Translocation 4;11 acute leukemia: three case reports and review of the literature
Author: Kocova, M
Author: Kowalczyk, J R
Author: Sandberg, A A
Abstract: Three children with acute leukemia and t(4;11)(q21;q23) are presented. Two of the cases showed very unusual karyotypic findings and long survival for the type of leukemia. In case B.T., the original karyotype change observed was t(4;11), with other changes (+4q-,+11q+,+6,+10) appearing during the last stages of the disease. In case R.B., the translocation was accompanied by many numerical and morphological chromosome changes, with a near-tetraploid chromosome number. In both of the above cases, remission was associated with a normal marrow karyotype. In case D.C., only the t(4;11) was observed. The number of cases with t(4;11) and acute leukemia published so far is 36, including the three cases presented by us. As this disease is usually characterized by a relatively short survival, the possible reasons for the remarkably long survival in two of our patients are discussed in relation to the rather unusual cytogenetic findings.
Publisher: Elsevier BV
Relation: Cancer Genetics and Cytogenetics
Identifier: oai:repository.ukim.mk:20.500.12188/11551
Identifier: 0165-4608
Identifier: http://hdl.handle.net/20.500.12188/11551Identifier: 10.1016/0165-4608(85)90074-3
Identifier: https://api.elsevier.com/content/article/PII:0165460885900743?httpAccept=text/xmlIdentifier: https://api.elsevier.com/content/article/PII:0165460885900743?httpAccept=text/plainIdentifier: 16
Identifier: 1
Identifier: 21
Identifier: 32
