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Year: 2007


Type: Article



Title: Organochloride Pesticides in Macedonian Girls With Premature Sexual Development


Author: M Krstevska-Konstantinova
Author: M Kocova
Author: C Charlier
Author: J Bourguignon



Abstract: Premature sexual development (PSD) in girls describes the appearance of secondary sexual signs before the age of 8 years. Early puberty is diagnosed if pubertal signs appear between the age of 8 and 9 years. We found a positive association between the levels of organochloride pesticides (p,p'-DDE) in precocious puberty in girls adopted from developing countries and significantly higher levels than in native Belgian girls with the same condition.We have compared the serum levels of eight p,p'- DDE in 56 Macedonian girls with PSD and a control group of 24 normal, age-matched girls, using a gas chromatographic analyzer coupled to a tandem mass spectrometer detector. Of the 56 girls with PSD, 42 had premature thelarche, five had early puberty, and nine had precocious puberty of idiopathic (n = 8) or organic (n = 1) origin. We found traces of p,p'- DDE in nine girls (16%) and negative results in 41 (73%), while the remaining six (10%) had a mean level of 1.17 ± 0.7 μg/L. In the control group, traces were found in one girl (4%) and negative results in 18 (75%), while the remaining five (20%) had a mean level of 1.18 ± 0.6 μg/L. We found elevated levels of lindane in the girls with PSD (mean value 1.2 ± 0.8) and significantly higher levels in the control group (1.4 ± 0.8) (<0.05). We concluded that Macedonian girls with PSD do not have higher levels of p,p'-DDE in their serum than the normal controls. However, the elevated levels of lindane in this population should be further investigated.


Publisher: Walter de Gruyter GmbH


Relation: Balkan Journal of Medical Genetics



Identifier: oai:repository.ukim.mk:20.500.12188/11543
Identifier: http://hdl.handle.net/20.500.12188/11543
Identifier: 10.2478/v10034-007-0008-3
Identifier: https://content.sciendo.com/view/journals/bjmg/10/1/article-p43.xml
Identifier: https://content.sciendo.com/downloadpdf/journals/bjmg/10/1/article-p43.xml
Identifier: 10
Identifier: 1
Identifier: 43
Identifier: 48



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Organochloride Pesticides in Macedonian Girls With Premature Sexual Development200724