Year: 2005
Type: Article
Title: Girls with Turner's syndrome with spontaneous menarche have an increased risk of endometrial carcinoma: a case report and review from the literature
Author: M. Kocova
Author: N. Basheska
Author: A. Papazovska
Author: R. Jankova
Author: D. Toncheva
Author: S. Popovska
Abstract: Background. Patients with Turner's syndrome receiving unopposed estrogens for the induction of feminization have an increased risk of endometrial carcinoma. Only seven patients who were not treated with estrogen replacement therapy have been reported to have developed endometrial carcinoma at different age levels. Case. A young girl with Turner's syndrome phenotype, spontaneous puberty, and karyotype 45,X0/47,XXX from peripheral blood, after irregular menstrual cycles of 9 years, at the age of 21, was diagnosed with a non-invasive well-differentiated endometrial carcinoma confined to a hyperplastic endometrial polyp. Analysis of the ovarian tissue by FISH confirmed mosaicism: 45,X0/46,XX/47,XXX. Conclusion(s). The endogenous estrogen secretion from the ovaries might have caused malignancy in this case. Patients with Turner's syndrome with spontaneous menarche might carry a higher risk of endometrial carcinoma.
Publisher: Elsevier BV
Relation: Gynecologic Oncology
Identifier: oai:repository.ukim.mk:20.500.12188/11158
Identifier: 0090-8258
Identifier: http://hdl.handle.net/20.500.12188/11158Identifier: 10.1016/j.ygyno.2004.10.048
Identifier: https://api.elsevier.com/content/article/PII:S0090825804008984?httpAccept=text/xmlIdentifier: https://api.elsevier.com/content/article/PII:S0090825804008984?httpAccept=text/plainIdentifier: 96
Identifier: 3
Identifier: 840
Identifier: 845
